Young mice plasma sevs: unlocking the secret to longevity

You remember the #1 issue of our Newsletter. We were pointing out longevity benefits of connecting your blood circulatory system to that of a YOUNG YOU. As it turned out you can achieve similar results in a simpler way. Read Hot Science below.

When Forbes addresses longevity investing as a new growing phenomenon,  both investors and biotech listen. Read Hot Investments below.

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Hot Science

We highlighted in the Newsletter #1 a groundbreaking discovery involving heterochronic parabiosis (HPB), a method that merges the circulatory systems of young and old animals, revealing that a protein in young blood can significantly reverse aging signs in vital tissues. A new study builds on this by examining the underlying mechanisms, demonstrating that small extracellular vesicles (sEVs) from young mice's plasma can counteract aging at molecular, mitochondrial, and cellular levels. These sEVs extend lifespan, reduce senescent phenotypes, and enhance mitochondrial function via PGC-1α expression, driven by their miRNA cargoes, thereby improving energy metabolism in aged tissues.
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There might be multiple additional mechanisms working on extending longevity in addition to sEVs in the HPB method. But if the introduction of sEVs provides a similar effect as HPB, it opens an important new path for development of longevity therapeutics bypassing the relatively complex HPB method. Immorta Bio believes that leveraging autologous iPSC derived progenitor cells for organ rejuvenation provides a superior solution to enhancing longevity. ‍

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Hot Investments

Forbes has recently published an article analyzing a new global phenomenon, the pursuit of longevity.  The article addresses the venture capital funds around the world that have recognized the immense potential of longevity breakthroughs and are specifically targeting that industry. On the one hand the article addresses some major hurdles the industry is facing, such as the difficulties of research, development, and commercialization. It also addresses the regulatory issues and ethical questions that pose additional challenges for founders and investors. On the other hand, it considers Investing In tomorrow and increasing the chances of achieving a healthier and longer life to be an incredible opportunity for both humanity and investors.

Immorta Bio believes that longevity industry provides a similar grandiose potential to its investors as some proven incredible investment phenomena of the past, computer automation, artificial intelligence,  financial industry.

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Longevity Shorts

• Celularity Inc. will present in vitro data at the ASGCT Annual Meeting demonstrating that their NK cell therapies are potent Senolytic agents, advancing senotherapeutic approaches in anti-aging efforts.

• A recent study finds that consuming 26 grams of freeze-dried strawberry powder daily boosts cognitive speed, lowers blood pressure, and enhances antioxidant levels in older adults, promoting brain and heart health.

• The Healthy Ageing and Prevention Index will be globally launched on May 28, 2024, at the Geneva Press Club, Switzerland, highlighting advancements in anti-aging and health longevity metrics.

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Term of the Day

Cell Therapy:  A burgeoning field in medicine, cell therapy, utilizes cells to treat or prevent diseases. This can involve transplanting healthy cells into a patient, such as in bone marrow transplants, or manipulating a patient's own cells for therapeutic benefit.

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Boris Reznik, PhD
Chairman